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Sedentary Lifestyle and APOE4 Negatively Impact Neurovascular Function in Awake Mice’s Visual Cortex


Researchers investigated the impact of APOE genotype on neurovascular function in mice by crossing murine APOE with human APOE. They implanted cranial windows on 2-month-old mice and measured activity levels, neurovascular function, and haemodynamic responses at different ages after providing them with an exercise wheel. The study found that mice exposed to wheel running were more active and showed increased capillary density and baseline sO2. Sedentary mice had lower capillary diameter and sO2 values. Exercise also increased vasomotion in pial arteries.

The study revealed that APOE4 genotype mice had reduced vasomotion and impaired haemodynamic responses to visual stimuli. APOE4 sedentary mice had decreased haemodynamic responses to neuronal activity. Additionally, they showed smaller neuronal calcium responses and impaired neurovascular coupling compared to APOE3 mice.

The amount of exercise correlated with different measures of neurovascular function, with an increase over time in the correlation between exercise levels and neurovascular function. Neurovascular coupling measures were found to have a stronger correlation with exercise compared to measures of basal neurovascular function. APOE4 mice showed lower correlation coefficients between exercise and basal neurovascular function compared to APOE3 mice.

The study identified two clusters of correlated variables, one comprising baseline haemodynamic responses and the other including all other variables. Principal component analysis revealed that APOE genotype and duration of the experiment may affect some underlying factors driving the pattern of responses observed in the variables.

In summary, the research indicates that APOE4 genotype and lack of exercise negatively impact neurovascular function in mice, suggesting the potential benefits of exercise on maintaining neurovascular health.

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